Multi-morbidity

1. Multi-morbidity raises the risk of weak-binder status on VSTMBT in humans (AOR = 1.863, 95% CI: 1.082–3.208, p = 0.025).

   “Significant positive associations with higher odds of WB effect were observed for multi‐morbidity (AOR = 1.863; 95% CI: 1.082 – 3.208; p = 0.025)”

   Humans

   A comparative analysis of analytic approaches for predicting performance on a putative behavioural marker for Alzheimer's disease

   AAIC 2025 abstract·Dec 25, 2025

1. Multi-morbidity raises the risk of depression in humans.

   “inadequate physical activity, and multi-morbidity were independent predictors of depression among elderly.”

   Humans

   Depression and its determinants among elderly living in Dibrugarh district, Assam: A community based cross-sectional study

   Indian journal of psychiatry·Nov 1, 2025

More on Depression

1. Oldest-old age group is associated with multi-morbidity in humans.

   “All of the oldest-old women of this study reported to suffer from more than two medical conditions simultaneously.”

   Humansfemales

   An investigation on the prevalence and patterns of multi-morbidity among a group of slum-dwelling older women of Kolkata, India

   BMC geriatrics·Jul 22, 2024

1. Older women is associated with multi-morbidity in humans (95.8%).

   “The overall prevalence of multi-morbidity was 95.8% in this group of older women.”

   Humansfemalesn = 500

   An investigation on the prevalence and patterns of multi-morbidity among a group of slum-dwelling older women of Kolkata, India

   BMC geriatrics·Jul 22, 2024

1. Multi-morbidity raises the risk of sleep problems in humans.

   “Older adults with multi-morbidity had higher odds of suffering from sleep problems [adjusted odds ratio (aOR):1.26, confidence interval (CI):1.10-1.45] than those who had no multi-morbidity.”

   Humansolder adultsn = 31,464

   Mediation of the association between multi-morbidity and sleep problems by pain and depressive symptoms among older adults: Evidence from the Longitudinal Aging Study in India, wave- 1

   PloS one·Feb 9, 2023

1. Multi-morbidity raises the risk of depressive symptoms in humans (77% higher odds).

   “older adults with multiple chronic diseases had 77% higher odds of having depressive symptoms as compared to those without a history of chronic disease”

   Humansmultivariable logistic regression model

   An association between multi-morbidity and depressive symptoms among Indian adults based on propensity score matching

   Scientific reports·Sep 15, 2022

More on Depressive symptoms

1. Multi-morbidity is associated with new-onset functional limitations in humans (Approximately twofold hazard ratios at ages ≥55 years; approximately threefold or higher at ages 40–54 years).

   “Persons with increased accumulation of chronic conditions experience increased risks of developing functional limitations compared to their peers.”

   HumansHighest versus lowest age-specific quartile of chronic condition count1 January 2006–31 October 2018n = 39,624

   Multi-morbidity and patient-reported functional limitations: a population-based cohort study

   Journal of multimorbidity and comorbidity·May 30, 2022