Medication-related osteonecrosis of the jaw

Disease

2 papers2 findings

  • Animals2

Interventions

1

Ozone

downin rats1

1 study
  1. Ozone protects against medication-related osteonecrosis of the jaw in rats.

    “the ZOL+OZ group exhibited improvement in alveolar bone and soft tissue healing, a decrease in nonvital bone area, and modulation of local inflammation.”

    Animalsin zoledronate-treated rats following molar extractionmandible0.7 mg/kgfemales

    Systemic Ozone Therapy Improves Oral Hard and Soft Tissue Healing in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Study in Senescent Female Rats

    BiomedicinesMay 20, 2025

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Associations

1

Peri-implantitis

upin rats1

1 study
  1. Peri-implantitis raises the risk of medication-related osteonecrosis of the jaw in rats.

    “Peri-implantitis increases the risk of medication-related osteonecrosis of the jaws associated with osseointegrated implants in rats treated with zoledronate”

    Animalsin zoledronate-treated rats with dental implantsmaxillafemales

    Peri-implantitis increases the risk of medication-related osteonecrosis of the jaws associated with osseointegrated implants in rats treated with zoledronate

    Scientific reportsJan 5, 2024

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Trial sponsors

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