Major haemorrhage

1. Aspirin increases major haemorrhage in humans (HR 1.24, 95% CI 1.10, 1.39).

   “Over the entire period, a higher rate of major haemorrhage was observed in the randomized aspirin group compared with placebo (HR 1.24, 95% CI 1.10, 1.39).”

   Human trialentire periodn = 19,114

   Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial

   European heart journal·7 Nov 2025

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1. Aspirin raises the risk of major haemorrhage in humans (HR 1.24, 95% CI 1.10-1.39).

   “aspirin was associated with an increased hazard for incident major haemorrhagic events across both ASPREE and ASPREE-XT (1·24; 1·10-1·39).”

   HumansASPREE and ASPREE-XT combinedalmost a decaden = 15,633

   Aspirin and healthy lifespan in older people: main outcome of the ASPREE-XT observational study

   The lancet. Healthy longevity·30 Sep 2025

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