Urinary albumin-to-creatinine ratio is associated with incident osteoarthritis in humans (HR 1.11 for microalbuminuria versus normoalbuminuria).
“a significant, dose-dependent link between UACR and OA, with HRs of 1.11 for microalbuminuria and 1.20 for macroalbuminuria compared to normo-albuminuria.”
HumansMicroalbuminuria (UACR 30 to 300 mg/g) compared with normoalbuminuria (UACR <30 mg/g); participants without osteoarthritis at baselineMedian follow-up of nearly 18 yearsn = 445,860
Compared with normal readings, moderately and highly elevated urine ratios had osteoarthritis hazard ratios, relative risk measures, of 1.11 and 1.20 over nearly 18…Compared with normal readings, moderately and highly elevated urine ratios had osteoarthritis hazard ratios, relative risk measures, of 1.11 and 1.20 over nearly 18 years.
An observational analysis of 6,232 adults aged 50 and older found indirect links through depression and physical difficulties, but no direct associations.An observational analysis of 6,232 adults aged 50 and older found indirect links through depression and physical difficulties, but no direct associations.
What changedLoneliness and social isolation were indirectly linked to new osteoarthritis through depression and declining physical function, with no direct links
The catchEarly osteoarthritis could cause chair-rise difficulty, reversing the modeled pathway