Idiopathic pulmonary arterial hypertension
4 papers1 finding
- Humans1
- Animals3
Associations
1Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
Idiopathic pulmonary arterial hypertension is associated with cellular senescence in human cells.
“levels of senescence marker, p16INK4A and senescence-associated β-galactosidase (SA-β-gal) activity are higher in PA endothelial cells (ECs) isolated from idiopathic pulmonary arterial hypertension (IPAH) patients”
Cellsin PAECs isolated from IPAH patients vs healthy individuals
Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
Frontiers in medicineSep 20, 2022
Trial sponsors
Company1 trialPhase 3136 people
1 trialPhase 28 people
Latest
American Journal of Physiology Cell Physiology
The HIF2α-dependent upregulation of SETDB1 facilitates hypoxia-induced functional and phenotypical changes of pulmonary microvascular endothelial cells
Experiments in ratsHypoxia and HIF signalling
American Journal of Respiratory Cell and Molecular Biology
SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension
Study in peoplePulmonary hypertension
Frontiers in Medicine
Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
Experiments in miceHypoxia and HIF signalling