Hypercapnia
Trial sponsors
1 trial62 people
Latest
10 in 12 monthsPhysiological Reports
Supraphysiological ascorbic acid infusion attenuates cerebrovascular dysfunction in middle-aged and older adults
Non-randomised trial in peopleAscorbic acid
Journal of Neuroendocrinology
Periestropause enhances hypoxia-induced panic and microglial remodelling without altering respiratory control
Experiments in ratsMechanisms
Experimental Gerontology
Effects of permissive hypercapnia on intraoperative cerebral oxygenation and early postoperative cognitive function in older patients with fragile brain function during the non-acute phase undergoing laparoscopic colorectal surgery: A randomized controlled trial
Trial in peopleInterventions
Journal of Cerebral Blood Flow and Metabolism
Resveratrol supplementation and caloric restriction exert sex-specific effects on cerebrovascular function in a rat model of Alzheimer's disease
Experiments in ratsDietary restriction
The Journal of Physiology
Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study
Cohort study of 82 peoplePopulations
AAIC 2025 Abstract
Cerebrovascular Reactivity in Older Adults with Enlarged Perivascular Spaces and White Matter Hyperintensities
Cross-sectional study of 118 peoplePopulations
AAIC 2025 Abstract
Cerebrovascular Reactivity in Older Adults with Enlarged Perivascular Spaces and White Matter Hyperintensities
Cross-sectional study of 118 peoplePopulations
Skeletal Muscle
Long-term DNA methylation changes induced by age and elevated CO₂ in skeletal muscle
Experiments in miceDNA methylation
Brain Communications
Near-lifespan mesoscopic optical imaging of cerebrovascular function reveals age and sex differences in preclinical Alzheimer's disease model
Experiments in miceMechanisms