Human immunodeficiency virus 1 infection

1. Human immunodeficiency virus 1 infection increases cellular senescence in humans.

   “Compared to NHC, PWH showed a lower CD4+/CD8+ ratio and increased activation, senescence, and inflammation”

   HumansPWH vs NHCperipheral blood77.8% malesn = 81

   Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era

   Journal of biomedical science·Aug 19, 2024

More on Cellular senescence

1. Human immunodeficiency virus 1 infection decreases CD4/CD8 ratio in humans.

   “Compared to NHC, PWH showed a lower CD4+/CD8+ ratio and increased activation, senescence, and inflammation”

   HumansPWH vs NHCperipheral blood77.8% malesn = 81

   Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era

   Journal of biomedical science·Aug 19, 2024

More on CD4/CD8 ratio

1. Human immunodeficiency virus 1 infection decreases CD4+ T cells in humans.

   “Massive CD4+ T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection.”

   Reviewin HIV-1 infection

   Mechanisms of immune aging in HIV

   Clinical science (London, England : 1979)·Jan 6, 2022

More on CD4+ T cells

1. Human immunodeficiency virus 1 infection increases inflammation in humans.

   “Massive CD4+ T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection.”

   Reviewin HIV-1-infected individuals

   Mechanisms of immune aging in HIV

   Clinical science (London, England : 1979)·Jan 6, 2022

More on Inflammation

1. Human immunodeficiency virus 1 infection is associated with atypical NK cell subsets in humans (40%).

   “Interestingly, 40% of PWH displayed atypical NK cell subsets, representing intermediate stages of NK-poiesis based on single-cell multiomic trajectory analysis.”

   Human trialduring the first 4 y of ART4 yn = 60

   Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy

   Journal of immunology (Baltimore, Md. : 1950)·Mar 29, 2024