Hallmark-related disease

Disease1 paper2 findings

Effects

Mortality

mediatesin humans1

1 study

Hallmark-related disease mediates mortality in humans (approximately 60%).
Humanssugar rationing during the first 1,000 days of life
Early life sugar rationing and ageing related diseases, biological ageing and mortality · Nature communications · 31 Jul 2026

Sugar rationing

downin humans1HR 0.91Low certainty

1 study

Sugar rationing is associated with hallmark-related disease in humans (HR 0.91, 95% CI 0.88-0.94).
Humanssugar rationing during the first 1,000 days of lifen = 64,809
Early life sugar rationing and ageing related diseases, biological ageing and mortality · Nature communications · 31 Jul 2026

Nature CommunicationsHumans7 Sep