Gallstone disease
3 papers4 findings
- Humans3
Upstream
1High-density lipoprotein
downin humans1
1 study
High-density lipoprotein
downin humans1
High-density lipoprotein protects against gallstone disease in humans.
“triglycerides and high-density lipoprotein are protective factors for gallstone formation.”
Humansmultivariate logistic regressionn = 37,440
BMC gastroenterology22 May 2026
Associations
3Waist circumference
upin humans1
1 study
Waist circumference
upin humans1
Waist circumference raises the risk of gallstone disease in humans.
“Age, waist circumference, aspartate aminotransferase and fasting blood glucose are risk factors for gallstone formation”
Humansmultivariate logistic regressionn = 37,440
BMC gastroenterology22 May 2026
Older age
upin humans1
1 study
Older age
upin humans1
older age raises the risk of gallstone disease in humans (11.88% vs 2.59%, P < 0.001).
“The incidence of gallstones in the elderly aged 65 years and above was significantly higher than that in the young and middle-aged group below 65 [11.88% (553 / 4653): 2.59% (848 / 32788)]”
Humansgeneral health examination cohortn = 37,440
BMC gastroenterology22 May 2026
GLP-1 receptor agonists
downin humans1RR 0.703
1 study
GLP-1 receptor agonists
downin humans1RR 0.703
GLP-1 receptor agonists lower the risk of gallstone disease in humans (RR 0.703; 95% CI: 0.567-0.872).
“gallstone disease (RR 0.703; 95% CI: 0.567-0.872; p=0.001)”
Humansfollowing bariatric surgery in non-diabetic adults5 years
MON-690 Impact of GLP-1 Receptor Agonists on Late Complications Following Bariatric Surgery
ENDO 2025 abstract22 Oct 2025