Fibrous dysplasia

1 paper2 findings

Humans1

Effects

1

Osteoblastic cluster

upin humans1

1 study

Fibrous dysplasia increases osteoblastic cluster in humans.
“FD bone showed an altered fibroblast composition with an FD-specific osteoblastic cluster.”
Humansbone
Single-cell analysis of human fibrous dysplasia bone reveals a fibrotic transcriptome and GNAS variants in endothelial, perivascular, and stromal cells
American journal of human genetics22 Aug 2025

Associations

1

Fibrotic transcriptome signature

upin humans1

1 study

Fibrous dysplasia is associated with fibrotic transcriptome signature in humans.
“We also identified a common fibrotic transcriptomic signature across FD cell lineages.”
Humansbone
Single-cell analysis of human fibrous dysplasia bone reveals a fibrotic transcriptome and GNAS variants in endothelial, perivascular, and stromal cells
American journal of human genetics22 Aug 2025

Trial sponsors

Natasha Appelman-Dijkstra
1 trialPhase 482 people
National Institute of Dental and Craniofacial Research
1 trialPhase 215 people

Latest

American Journal of Human Genetics24 Aug

Single-cell analysis of human fibrous dysplasia bone reveals a fibrotic transcriptome and GNAS variants in endothelial, perivascular, and stromal cells

Cross-sectional study in peopleBones and joints