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Mechanical circulatory support

Mechanical circulatory support has been studied in 18 papers since 2019: 12 observational studies in people, 6 reviews; 5 in the past year. The newest story, Nov 7, 2026: “Frailty linked to more deaths in heart failure-related shock”.

Exposure

18 papers study it5 findingsUpdated

2 new papers in 30 daysSee all 18 papers on mechanical circulatory support

At a glance

The findings reach people, from one lab or study. 4 independent labs in 4 countries.

“Frailty independently predicted higher mortality and lower use of mechanical circulatory support in patients with CS.”
Sex Differences in Frailty-Associated Outcomes of Patients with Cardiogenic ShockShock (Augusta, Ga.)2025doi:10.1097/shk.0000000000002650

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 4 independent labs in 4 countries
  • Funders: National Center for Advancing Translational Sciences and 3 more
  • 3 of 5 findings with company ties
  • Humans12

What did studies of mechanical circulatory support find?

2

Studies of mechanical circulatory support measured 2 outcomes: cardiovascular death or heart failure hospitalization and frailty.

Cardiovascular death or heart failure hospitalization

no changein humans1HR 1.45

1 study

  1. Mechanical circulatory support was not clearly linked with cardiovascular death or heart failure hospitalization in humans (HR 1.45, 95% CI 0.93-2.26, P=0.10).

    “there was no statistically significant difference in cardiovascular death or heart failure hospitalization between the groups with or without the use of MCS (hazard ratio, 1.45 [95% CI, 0.93-2.26]; P=0.10).”

    Humansin landmark analysis starting from discharge date, comparing groups with or without MCS usen = 3,764

    Safety and Prognostic Implications of Mechanical Circulatory Support-Assisted Transcatheter Edge-to-Edge Repair: The OCEAN-Mitral Registry

    Journal of the American Heart Association

Frailty

downin humans1−76%

1 study

  1. Mechanical circulatory support is linked with lower frailty in humans (postoperative following MCS) (75.9%).

    “The majority (n = 22/29, 75.9%) of frail patients became non-frail following MCS”

    Humanspostoperative following MCSn = 29

    Impact of frailty on mortality and morbidity in bridge to transplant recipients of contemporary durable mechanical circulatory support

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

What is mechanical circulatory support linked with?

1

Studies link mechanical circulatory support with Hospital Frailty Risk score.

Hospital Frailty Risk score

downin humans1

1 study

  1. Hospital Frailty Risk score predicts mechanical circulatory support in humans (cardiogenic shock).

    “Frailty independently predicted higher mortality and lower use of mechanical circulatory support in patients with CS.”

    Humanscardiogenic shock

    Sex Differences in Frailty-Associated Outcomes of Patients with Cardiogenic Shock

    Shock (Augusta, Ga.)

More on Hospital Frailty Risk score

What acts on mechanical circulatory support?

1

Studies name frailty as acting on mechanical circulatory support.

Frailty

downin humans2

2 studies

  1. Frailty is linked with lower mechanical circulatory support in patients with acute myocardial infarction complicated by cardiogenic shock (aOR 0.89, 95% CI 0.85–0.93).

    “or mechanical circulatory support (aOR: 0.89, 95% CI: 0.85-0.93, P < 0.001).”

    Humansin patients with acute myocardial infarction complicated by cardiogenic shock

    Association Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock

    JACC. Advances

  2. Frailty is linked with lower mechanical circulatory support in humans (non-acute myocardial infarction with cardiogenic shock).

    “non-AMI-CS hospitalizations in the frail group had lower use of mechanical circulatory support but not rates of cardiac transplantation.”

    Humansnon-acute myocardial infarction with cardiogenic shockn = 503,780

    Frailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction

    Journal of clinical medicine

Funding

1 grant since 2022

Gouvernement du Canada | Canadian Institutes of Health ResearchCA$110K

Latest

Dec 2025: 2Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 15 papers in 12 months
AHA Scientific Sessions 2026 Abstract

Frailty linked to more deaths in heart failure-related shock

In-hospital mortality was 37.1% in the high-frailty group versus 16.3% in the low-frailty group in a national database analysis.In-hospital mortality was 37.1% in the high-frailty group versus 16.3% in the low-frailty group in a national database analysis.

Cohort · 203,272 peopleHeart failure
Paper
JACC Advances

Older cardiac intensive care patients had higher hospital death odds

Compared with adults under 65, adjusted hospital-death odds were 1.83 times as high at 75–84 and 1.95 at 85-plus; age differences were greater after cardiac arrest.Compared with adults under 65, adjusted hospital-death odds were 1.83 times as high at 75–84 and 1.95 at 85-plus; age differences were greater after cardiac arrest.

Cohort · 35,265 peoplePopulations
Paper

See all 18 papers on mechanical circulatory support

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