Elevated depressive symptoms

Cardiometabolic physical multimorbidity phenotype has no effect on elevated depressive symptoms in humans.

“Cardiometabolic-class estimates were null.”

HumansHistory of stroke; cardiometabolic versus low-comorbidity class

Physical Multimorbidity Phenotypes and Elevated Depressive Symptoms Among Chinese Adults With a History of Stroke: Derivation and Temporal Validation in CHARLS

Research Square·6 Oct 2026Preprint

High-complexity physical multimorbidity phenotype is associated with elevated depressive symptoms in humans (Validation aOR 1.74, 95% CI 1.17–2.60; derivation aOR 2.59, 95% CI 1.30–5.16).

“The association replicated in the temporal validation sample (n = 782; aOR 1.74, 1.17–2.60) and in a response-weighted analysis (1.93, 1.22–3.06).”

HumansHistory of stroke; temporal validation; high-complexity versus low-comorbidity classn = 782

Physical Multimorbidity Phenotypes and Elevated Depressive Symptoms Among Chinese Adults With a History of Stroke: Derivation and Temporal Validation in CHARLS

Research Square·6 Oct 2026Preprint