Diabetic neuropathic pain

2 papers2 findings

Animals2

Interventions

1

Metformin

downin mice1

1 study

Metformin decreases diabetic neuropathic pain in mice.
“Metformin in vivo treatment alleviated neuroinflammation and diabetic neuropathic pain by rescuing hyperglycemia-induced Sirt3 downregulation.”
Animalsin vivo
Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis
CNS neuroscience & therapeuticsAug 1, 2024

More on Metformin

Upstream

1

SIRT3

downin mice1

1 study

SIRT3 protects against diabetic neuropathic pain in mice.
“Sirt3 deficiency exacerbated hyperglycemia-induced neuroinflammation and DNP”
Animalshyperglycemia
Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis
CNS neuroscience & therapeuticsAug 1, 2024

Trial sponsors

Wake Forest University
1 trialPhase 422 people

Latest

Molecular NeurobiologyMar 25

SIRT1 Attenuates Neuropathic Pain via CDK5-Kalirin-7 Signaling Pathway in Type 2 Diabetic Rats

Experiments in ratsSirtuin signalling

CNS Neuroscience & TherapeuticsAug 1

Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis

Experiments in miceInterventions