Confluent white-matter lesions and lacunes

1 finding

Associations

Striatal DRD2 decline

upin humans1

1 study

Confluent white-matter lesions and lacunes predict striatal DRD2 decline in humans (DRD2 change: approximately −4% with both manifestations, −2% with one, and 0% with neither).
“Manifestations of confluent lesions and lacunes at baseline had additive effects on DRD2 decline.”
Humanshealthy older adultsstriatum5 yearsn = 129
Cerebral small-vessel disease severity, hypertension, and body mass index forecast striatal dopamine D2-receptor decline rates in aging
Neurobiology of aging6 Aug 2025