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Childhood-onset epilepsy

Disease

1 paper3 findings

  • Humans1

Effects

2

Episodic memory

downin humans1

1 study

  1. Childhood-onset epilepsy impairs episodic memory in humans.

    “A significant decline was found in participants with active epilepsy in episodic memory functions overall”

    Humansactive epilepsy7 years

    Cognitive decline over 7 years in aging patients with childhood-onset epilepsy: A population-based prospective follow-up study

    Journal of the International Neuropsychological Society : JINS15 Jul 2025

Cognitive decline

no changein humans1OR 2.19

1 study

  1. Childhood-onset epilepsy has no effect on cognitive decline in humans (OR 2.19, 95% CI 0.58-8.23, p = .24).

    “Among those with remitted epilepsy the risk was lower and non-significant (OR 2.19, 95% CI 0.58-8.23, p = .24).”

    Humansremitted epilepsy7 yearsn = 28

    Cognitive decline over 7 years in aging patients with childhood-onset epilepsy: A population-based prospective follow-up study

    Journal of the International Neuropsychological Society : JINS15 Jul 2025

Associations

1

Cognitive decline

upin humans1

1 study

  1. Childhood-onset epilepsy raises the risk of cognitive decline in humans (OR 61.25, 95% CI 5.92-633.81, p = .0006).

    “The risk of clinically significant general cognitive decline was higher in participants with active epilepsy (OR 61.25, 95% CI 5.92-633.81, p = .0006).”

    Humansactive epilepsy7 yearsn = 8

    Cognitive decline over 7 years in aging patients with childhood-onset epilepsy: A population-based prospective follow-up study

    Journal of the International Neuropsychological Society : JINS15 Jul 2025

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