Chemotherapy-associated aplastic anemia

1. ASXL1 is associated with chemotherapy-associated aplastic anemia in humans (FDR=0.047).

   “compared with patients with non-AA cancer, those with CAA had higher mutation frequencies in 198 genes, including BRCA2 (FDR=0.032) and ASXL1 (FDR=0.047)”

   Humanscompared with non-AA cancerperipheral bloodn = 24

   Somatic and immune profiling of chemotherapy-associated aplastic anemia: a comparison with primary aplastic anemia and cancer without aplastic anemia

   Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·14 May 2026

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1. HLA-DRB1 is associated with chemotherapy-associated aplastic anemia in humans (FDR =0.029).

   “the mutation frequency of HLA-DRB1 was higher in patients with CAA than in those with non-AA cancer [false discovery rate (FDR) =0.029]”

   Humanscompared with non-AA cancerperipheral bloodn = 24

   Somatic and immune profiling of chemotherapy-associated aplastic anemia: a comparison with primary aplastic anemia and cancer without aplastic anemia

   Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·14 May 2026

More on HLA-DRB1