Atypical femur fracture: aging research evidence

Interventions

1

Bisphosphonates

upin silico1

1 study

Bisphosphonates increase atypical femur fracture in silico (19,464 atypical femur fractures).
“with bisphosphonates would avoid 94,888 lifetime hip fractures at the cost of 19,464 atypical femur fractures”
In silicoAfter distal radius fractureLifetimeFemales
Economic Analysis of Bisphosphonate Use after Distal Radius Fracture for Prevention of Hip Fracture
The archives of bone and joint surgeryNov 1, 2017

Associations

2

Asian race/ethnicity

upin humans1

1 study

Asian race/ethnicity raises the risk of atypical femur fracture in humans (IRR 4.96 (CI, 3.72-6.61)).
“the IRR for AFF risk in Asian women (compared to White women) was 4.96 (CI, 3.72-6.61)”
Humansin older adult women with bisphosphonate use, adjusting for age, cumulative duration of BP use, and recency of BP usefemales
Association of exercise and race/ethnicity with atypical femur fracture
JBMR plusApr 23, 2025

Asian race

upin humans1

1 study

Asian race raises the risk of atypical femur fracture in humans.
“among women receiving bisphosphonate drugs, Asian race is a risk factor for atypical femur fracture, an uncommon complication associated with treatment duration.”
Reviewamong women receiving bisphosphonate drugsfemales
Osteoporosis and Fracture Risk among Older US Asian Adults
Current osteoporosis reportsAug 5, 2023

Funding

3 grants since 2018

National Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$5.3mGouvernement du Canada | Canadian Institutes of Health ResearchCA$2mNational Health and Medical Research CouncilA$1.1m