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Atherosclerotic cardiovascular disease incidence

There are 5 papers on atherosclerotic cardiovascular disease incidence in aging research: 5 observational studies in people. The newest story, Oct 26, 2026: “Blood particle linked to highest artery disease risk at 70–100”.

Disease

5 papers study it2 more mention it10 findings

5 new papers in 30 daysSee all 7 papers on atherosclerotic cardiovascular disease incidence

“Generally, FHA was consistently associated with higher ASCVD risk, but the association weakened with age (Pinteraction < 0.001).”
Family History and ASCVD Risk Among Different Age Groups: Cohort Study in China and the United KingdomJACC. Asia2026doi:10.1016/j.jacasi.2025.10.031
  • Humans5

Interventions

1

Dietary magnesium intake

no changein humans1HR 1.01

1 study

  1. Dietary magnesium intake was not clearly linked with atherosclerotic cardiovascular disease incidence in humans (Participants without type 2 diabetes) (HR 1.01, 95% CI 0.94–1.09).

    “no significant association was observed in participants without type 2 diabetes (1.01 [0.94;1.09] for ASCVD incidence;”

    HumansParticipants without type 2 diabetesEqual to or greater than the recommended daily intakeMedian follow-up of 12.0 years

    Associations of dietary magnesium intake with the risk of atherosclerotic cardiovascular disease and mortality in individuals with and without type 2 diabetes: A prospective study in the UK Biobank

    Diabetes & metabolism

More on Dietary magnesium intake

Associations

8

Apolipoprotein B

upin humans1

1 study

  1. Apolipoprotein B predicts atherosclerotic cardiovascular disease incidence in humans (Incidence rate difference 2.23/1,000 person-years; 12.81 versus 10.58/1,000 person-years).

    “Additionally, high ApoB showed predictive value in individuals with high PRS (IR 12.81 vs. 10.58/1,000 PY, ΔIR 2.23, p=0.004)”

    HumansControlled LDL-C (<100 mg/dL), coronary artery disease polygenic risk score in top quintile; ApoB ≥80 mg/dL versus low ApoB

    Apolipoprotein B beyond LDL-cholesterol in predicting Atherosclerotic Cardiovascular Disease risk in high-risk populations

    ESC Congress 2026 abstract

  2. Apolipoprotein B is associated with atherosclerotic cardiovascular disease incidence in humans (Incidence rate difference 0.63/1,000 person-years; 1.80 versus 1.17/1,000 person-years).

    “High ApoB was associated with increased ASCVD risk (IR 1.80 vs. 1.17/1,000 PY, ΔIR 0.63, p=0.045) in individuals with no other REF (n=8,459).”

    HumansControlled LDL-C (<100 mg/dL), no other risk-enhancing factors; ApoB ≥80 mg/dL versus low ApoBn = 8,459

    Apolipoprotein B beyond LDL-cholesterol in predicting Atherosclerotic Cardiovascular Disease risk in high-risk populations

    ESC Congress 2026 abstract

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Lipoprotein(a) and fibrinogen

upin humans1HR 1.904

1 study

  1. Lipoprotein(a) and fibrinogen is associated with atherosclerotic cardiovascular disease incidence in humans (jointly elevated lipoprotein(a) and fibrinogen) (HR 1.904, 95% CI 1.023–3.547).

    “Participants with both elevated Lp(a) and fibrinogen levels demonstrated the highest 20-year ASCVD risk (HR 1.904, 95%CI [1.023, 3.547]).”

    Humansjointly elevated lipoprotein(a) and fibrinogen20 years

    The interplay of fibrinogen and lipoprotein(a) with 20-year atherosclerotic cardiovascular disease risk: a path analysis within the ATTICA study (2002-2022)

    European journal of preventive cardiology

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Fibrinogen

upin humans1HR 1.04

1 study

  1. Fibrinogen is associated with atherosclerotic cardiovascular disease incidence in humans (initially cardiovascular disease-free adults) (HR 1.040 per 10 mg/dL, 95% CI 1.009–1.072).

    “In the overall cohort, fibrinogen was associated with higher ASCVD risk [hazard ratio (HR) per 10 mg/dL: 1.040, 95%CI:1.009-1.072].”

    Humansinitially cardiovascular disease-free adults20 years

    The interplay of fibrinogen and lipoprotein(a) with 20-year atherosclerotic cardiovascular disease risk: a path analysis within the ATTICA study (2002-2022)

    European journal of preventive cardiology

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C-reactive protein

no changein humans1OR 1.06

1 study

  1. C-reactive protein is associated with atherosclerotic cardiovascular disease incidence in humans (OR 1.06, 95% CI 0.94-1.19, p=0.32).

    “After adjustment, hs-CRP was not independently associated with ASCVD (OR 1.06, 95% CI 0.94-1.19, p=0.32).”

    HumansAdjusted for variables used in the PREVENT calculation; no prior ASCVD and PREVENT 10-year ASCVD risk <5%8 yearsn = 2,149

    Elevated High-Sensitivity C-Reactive Protein as a Prescribing Trigger versus a Risk-Enhancing Factor Identifies Distinct Primary Prevention Populations for Statin Therapy

    AHA Scientific Sessions 2026 abstract

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Borderline-risk refinement strategy

upin humans1

1 study

  1. Borderline-risk refinement strategy is associated with atherosclerotic cardiovascular disease incidence in humans (Compared with the hs-CRP-driven strategy and no statin indication) (9.8% versus 4.4% with the hs-CRP-driven strategy and 2.6% with no statin indication).

    “Despite higher ASCVD event rate in the Borderline-Risk Refinement Strategy group”

    HumansCompared with the hs-CRP-driven strategy and no statin indication8 yearsn = 2,149

    Elevated High-Sensitivity C-Reactive Protein as a Prescribing Trigger versus a Risk-Enhancing Factor Identifies Distinct Primary Prevention Populations for Statin Therapy

    AHA Scientific Sessions 2026 abstract

More on Borderline-risk refinement strategy

Sibling history of atherosclerotic cardiovascular disease

upin humans1

1 study

  1. Sibling history of atherosclerotic cardiovascular disease is associated with atherosclerotic cardiovascular disease incidence in humans (Compared with parental history).

    “Notably, sibling history conferred greater risk than parental history (Pheterogeneity < 0.001).”

    HumansCompared with parental history

    Family History and ASCVD Risk Among Different Age Groups: Cohort Study in China and the United Kingdom

    JACC. Asia

Family history of atherosclerotic cardiovascular disease

upin humans1HR 1.48

1 study

  1. Family history of atherosclerotic cardiovascular disease is associated with atherosclerotic cardiovascular disease incidence in humans (Family history of atherosclerotic cardiovascular disease; China-PAR and UK Biobank) (China-PAR: HR 1.48 (95% CI 1.11–1.96); UK Biobank: HR 1.47 (95% CI 1.23–1.76)).

    “Generally, FHA was consistently associated with higher ASCVD risk, but the association weakened with age (Pinteraction < 0.001).”

    HumansFamily history of atherosclerotic cardiovascular disease; China-PAR and UK Biobank

    Family History and ASCVD Risk Among Different Age Groups: Cohort Study in China and the United Kingdom

    JACC. Asia

Dietary magnesium intake

downin humans1HR 0.63

1 study

  1. Dietary magnesium intake is associated with atherosclerotic cardiovascular disease incidence in humans (Participants with type 2 diabetes) (HR 0.63, 95% CI 0.49–0.82).

    “Sufficient dietary Mg intake was significantly associated with lower risks of ASCVD events and mortality in individuals with type 2 diabetes”

    HumansParticipants with type 2 diabetesEqual to or greater than the recommended daily intakeMedian follow-up of 12.0 yearsn = 4,603

    Associations of dietary magnesium intake with the risk of atherosclerotic cardiovascular disease and mortality in individuals with and without type 2 diabetes: A prospective study in the UK Biobank

    Diabetes & metabolism

More on Dietary magnesium intake

Latest

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ESC Congress 2026 Abstract

Blood particle linked to highest artery disease risk at 70–100

The observational cohort included 20,723 adults aged 70–100; those with high levels of the cholesterol-carrying particle had the highest absolute risk.The observational cohort included 20,723 adults aged 70–100; those with high levels of the cholesterol-carrying particle had the highest absolute risk.

Cohort · 20,723 peoplePopulations
Paper

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