Argyrophilic grain disease

1. Argyrophilic grain disease is associated with parkinsonism in humans (6 of 20 cases).

   “Six among 20 cases presented with parkinsonism, especially postural instability in addition to amnestic dementia”

   Humanspure AGD with dementia casesn = 20

   Prevalence of argyrophilic grain disease and its clinical impact on cognitive decline and parkinsonism in a consecutive autopsy cohort in Japan

   AAIC 2025 abstract·24 Dec 2025

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1. Argyrophilic grain disease raises the risk of dementia in humans (46.7% vs 27.1%, CDR 1.2 ± 1.2 vs 0.8 ± 1.2).

   “The rate of demented cases and average CDR score were significantly higher in AGD positive cases (46.7% and 1.2 ± 1.2) than AGD negative cases (27.1% and 0.8 ± 1.2).”

   Humansautopsy cohortbrainn = 452

   Prevalence of argyrophilic grain disease and its clinical impact on cognitive decline and parkinsonism in a consecutive autopsy cohort in Japan

   AAIC 2025 abstract·24 Dec 2025

More on Dementia