Alzheimer's disease-related cognitive impairment

1. Alzheimer's disease-related cognitive impairment is associated with Extrinsic epigenetic age acceleration in humans.

   “EAA measures indicated higher acceleration in the ADCI group compared to the CU group, particularly for extrinsic epigenetic age acceleration (EEAA), AgeAccelResidualHannum, and AgeAccelPheno”

   Humansin both men and womenblood

   Sex-specific accelerated epigenetic aging in the Alzheimer's disease spectrum

   Journal of Alzheimer's disease : JAD·26 Mar 2026

2. Extrinsic epigenetic age acceleration raises the risk of Alzheimer's disease-related cognitive impairment in humans.

   “increased EEAA, the presence of APOE ɛ4 allele, and poorer nutritional status were significantly associated with a higher likelihood of ADCI”

   Humansin men and womenblood

   Sex-specific accelerated epigenetic aging in the Alzheimer's disease spectrum

   Journal of Alzheimer's disease : JAD·26 Mar 2026

More on Extrinsic epigenetic age acceleration

1. APOE raises the risk of Alzheimer's disease-related cognitive impairment in humans.

   “increased EEAA, the presence of APOE ɛ4 allele, and poorer nutritional status were significantly associated with a higher likelihood of ADCI”

   Humansblood

   Sex-specific accelerated epigenetic aging in the Alzheimer's disease spectrum

   Journal of Alzheimer's disease : JAD·26 Mar 2026

More on APOE