YY1 occupancy at promoters and super-enhancers

Stem-cell aging is associated with YY1 occupancy at promoters and super-enhancers in human cells.

“YY1 is highly enriched at both promoters and SEs in young cells but is depleted from these loci in old cells.”

Cellsyoung versus in-vitro-aged cellsmesenchymal stem cell

Disruption of YY1-mediated super-enhancer-promoter looping drives transcriptomic changes during mammalian stem-cell aging

Research square·6 Jun 2025Preprint