Vascular MHC II

1. Vascular MHC II increases CD4+ T-cell extravasation in mice.

   “upregulates vascular MHC II to promote extravasation of CD4 + T cells into the aging tissue.”

   Animalsadipose tissue

   Senescent cells induce vascular MHC II to recruit CD4 + T cells and drive inflammation in aging adipose tissue

   bioRxiv (Cold Spring Harbor Laboratory)·16 May 2026Preprint

1. Cellular senescence increases vascular MHC II in mice.

   “senescent cells act as an upstream trigger, indirectly initiating an IFNγ response that upregulates vascular MHC II”

   Animalsadipose tissue

   Senescent cells induce vascular MHC II to recruit CD4 + T cells and drive inflammation in aging adipose tissue

   bioRxiv (Cold Spring Harbor Laboratory)·16 May 2026Preprint

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