Urinary titin N-fragment
Biomarker1 paper2 findings
- Human trial1
Interventions
1Empagliflozin
upin humans1Very low certainty
1 study
Empagliflozin
upin humans1Very low certainty
Empagliflozin increases urinary titin N-fragment in humans (from 1.7 (IQR 1.1-3.5) to 2.4 (IQR 1.3-4.2) pmol/mg Cr, p = 0.040).
Human trialstable congestive heart failureurine10 mg daily6 monthsn = 93
Association between empagliflozin exposure and skeletal muscle degeneration in patients with heart failure · BMC cardiovascular disorders · 31 Aug 2026
Associations
1Left ventricular ejection fraction ≥50%
upin humans1OR 3.31
1 study
Left ventricular ejection fraction ≥50%
upin humans1OR 3.31
Left ventricular ejection fraction ≥50% predicts urinary titin N-fragment in humans (OR 3.31, 95% CI 1.23-9.52, p = 0.017).
Human trialstable congestive heart failure, empagliflozin treatment10 mg daily6 monthsn = 93
Association between empagliflozin exposure and skeletal muscle degeneration in patients with heart failure · BMC cardiovascular disorders · 31 Aug 2026