tRFs

1. Traumatic brain injury is associated with tRFs in humans.

   “in cerebrospinal fluid from traumatic brain injury patients, suggesting that tRF accumulation is further amplified under neurological stress.”

   Humansin traumatic brain injury patientscsf

   tRNA-derived fragments are elevated in the aging brain and may contribute to neurodegeneration

   bioRxiv : the preprint server for biology·19 May 2026Preprint

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1. Frontotemporal dementia is associated with tRFs in humans.

   “Analogous upregulation was observed in human frontal lobe tissue from frontotemporal dementia patients”

   Humansin frontotemporal dementia patientsfrontal lobe

   tRNA-derived fragments are elevated in the aging brain and may contribute to neurodegeneration

   bioRxiv : the preprint server for biology·19 May 2026Preprint

More on Frontotemporal dementia