Trans-ancestry CAD polygenic risk scores

Trans-ancestry CAD polygenic risk scores improve CAD risk prediction performance in humans (Approximately 60% and 90% increases in pseudo-R 2 relative to East Asian-specific and European-specific PRSs, respectively).

“Both trans-ancestry PRSs showed approximately 60% and 90% increases in pseudo-R 2 relative to the top-performing East Asian-specific and European-specific PRSs, respectively.”

HumansChinese training set; comparison with top-performing East Asian-specific and European-specific PRSs

Genetic scores better predict coronary artery disease in China

Genome medicine·Oct 17, 2026