Total DNA Methylation Activity
1 paper2 findings
- In silico1
Associations
2Chronological age
mixedin silico1
1 study
Chronological age
mixedin silico1
Total DNA Methylation Activity is associated with chronological age in silico.
“we further reveal strong associations between the predicted total methylation activity, chronological aging, and established epigenetic clocks.”
In silicoGTEx
bioRxiv (Cold Spring Harbor Laboratory)2 Feb 2026Preprint
Methionine and one-carbon metabolism model
mixedin silico1
1 study
Methionine and one-carbon metabolism model
mixedin silico1
methionine and one-carbon metabolism model predicts Total DNA Methylation Activity in silico.
“a compact metabolic model comprising seven core reaction steps and 98 genes accurately predicts total DNA methylation activity”
In silicoMatched transcriptomic and methylation datasets from CCLE, TCGA, GTEx, and an independent single-cell multi-omics dataset
bioRxiv (Cold Spring Harbor Laboratory)2 Feb 2026Preprint