Total ACE score

Total ACE score has no effect on baseline global cognition and annual rate of global cognitive decline in humans.

“Total ACE score was not associated with baseline global cognition or with the annual rate of global cognitive decline.”

HumansWithout dementia at baselineMean follow-up 7.6 years26% malesn = 1,869

Association of Adverse Childhood Experiences and Cognitive Health in Older Adults: Rush Memory and Aging Project

The American journal of geriatric psychiatry. Open science, education, and practice·5 May 2026