Thymic cellularity

1. Maternal protein restriction increases thymic cellularity in mice.

   “Offspring of dams fed a postnatal low-protein (PLP) diet during lactation had a significant increase in thymic cellularity and T cell numbers across their lifespan compared to controls”

   Animalsmaternal postnatal low-protein diet during lactationthymus

   The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice

   Oncotarget·Feb 9, 2016

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1. CYP27B1 increases thymic cellularity in mice.

   “mice lacking Cyp27b1, which cannot produce hormonally active vitamin D, display profoundly reduced thymic cellularity”

   Animalsshown by knockoutthymus

   Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin D signaling

   Science advances·Sep 25, 2024

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