Tau abundance

1. Cognitively intact centenarian status is associated with tau abundance in humans.

   “One-third of centenarians had high Aβ abundance, often with Braak neurofibrillary tangle stages IV/V, yet all maintained low local tau abundance.”

   Humanscognitively intact centenariansmiddle temporal gyrusn = 49

   Cognitively Healthy Centenarian Brains resist Tau Accumulation and exhibit lower APOE, early proteasome response and maintained β-oxidation

   medRxiv·8 Jan 2026Preprint

1. GPRIN1 is associated with tau abundance in humans.

   “tau abundance associated with ∼20% of the quantified proteome, revealing GPRIN1 as the top tau-associated protein.”

   Humansmiddle temporal gyrus

   Cognitively Healthy Centenarian Brains resist Tau Accumulation and exhibit lower APOE, early proteasome response and maintained β-oxidation

   medRxiv·8 Jan 2026Preprint

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