Symmetric dimethylarginine

1. Functional food bioactives decrease symmetric dimethylarginine in dogs (FF2) (-14.3%).

   “Dogs fed the highest supplemented level of bioactives (FF2) had lower (P<0.001) symmetric dimethylarginine (SDMA) concentrations (-14.3%).”

   AnimalsFF26 monthsn = 27

   Nutritional Interventions that Slow the Age-Associated Decline in Renal Function in a Canine Geriatric Model for Elderly Humans

   The journal of nutrition, health & aging·Jan 1, 2016

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1. Symmetric dimethylarginine is linked with red blood cell distribution width in humans.

   “In all three cohorts, symmetric dimethylarginine (SDMA) significantly mediated the association between age and RDW.”

   Humans

   Metabolomic markers mediate erythrocyte anisocytosis in older adults: Results from three independent aging cohorts

   Journal of internal medicine·Feb 6, 2023

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1. Symmetric dimethylarginine is associated with glomerular filtration rate in humans across declining glomerular filtration rate categories (P < 0.0001).

   “Plasma symmetric dimethylarginine increased consistently across declining glomerular filtration rate categories ( P < 0.0001).”

   Humansacross declining glomerular filtration rate categoriesn = 394

   Symmetric dimethylarginine is a stronger predictor of mortality risk than asymmetric dimethylarginine among older people with kidney disease

   Annals of clinical biochemistry·Feb 27, 2019

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1. Symmetric dimethylarginine is linked with a higher risk of mortality in humans (independently associated) (P < 0.0001; a stronger predictor than asymmetric dimethylarginine).

   “High plasma asymmetric dimethylarginine ( P = 0.0412) and symmetric dimethylarginine ( P < 0.0001) concentrations were independently associated with reduced survival.”

   Humansindependently associatedmedian 33 months

   Symmetric dimethylarginine is a stronger predictor of mortality risk than asymmetric dimethylarginine among older people with kidney disease

   Annals of clinical biochemistry·Feb 27, 2019

1. Symmetric dimethylarginine is associated with incident mobility disability in humans (Initially free of mobility disability) (HR 3.58, 95% CI 1.57–8.15).

   “symmetric dimethylarginine; HR = 3.58, 95% CI = 1.57-8.15”

   HumansInitially free of mobility disabilityplasma13 yearsmalesn = 307

   Metabolites Associated With Risk of Developing Mobility Disability in the Health, Aging and Body Composition Study

   The journals of gerontology. Series A, Biological sciences and medical sciences·Dec 1, 2017