There are 5 papers on substantia nigra hyperechogenicity in aging research: 5 observational studies in people.
5 papers study it8 findings
1 new paper in 30 daysSee all 5 papers on substantia nigra hyperechogenicity
“The most significant predictors of conversion were hyperechogenicity of the substantia nigra on transcranial Doppler (TCD), absence of nigrosome-1 on MRI,”
- Humans5
Effects
1Short-interval intracortical inhibition
no changein humans1
1 study
Short-interval intracortical inhibition
no changein humans1
Substantia nigra hyperechogenicity was not clearly linked with short-interval intracortical inhibition in humans (healthy adults).
“There was no relationship between area of SN echogenicity and short-interval intracortical inhibition in the ipsilateral primary motor cortex.”
Humanshealthy adultsprimary motor cortexn = 23
Journal of neuroscience research
Upstream
1PRKN
no changein humans1
1 study
PRKN
no changein humans1
PRKN was not clearly linked with substantia nigra hyperechogenicity in humans (heterozygous Parkin mutation carriers vs non-carriers).
“We observed no differences concerning motor or non-motor symptoms and substantia nigra hyperechogenicity.”
Humansheterozygous Parkin mutation carriers vs non-carrierssubstantia nigra
Parkinsonism & related disorders
Associations
5Verbal memory
downin humans2
2 studies
Verbal memory
downin humans2
Substantia nigra hyperechogenicity is associated with verbal memory in humans (at risk of DLB).
“SN+ status as compared to SN- status was associated with poorer verbal memory performance”
Humansat risk of DLBn = 121
Journal of neural transmission (Vienna, Austria : 1996)
Substantia nigra hyperechogenicity is associated with verbal memory in humans (healthy individuals; hyperechogenicity compared with no hyperechogenicity).
“In both cohorts, SN+ individuals performed significantly worse than the SN- group in tests assessing verbal memory”
Humanshealthy individuals; hyperechogenicity compared with no hyperechogenicity
Substantia nigra hyperechogenicity is related to decline in verbal memory in healthy elderly adults
European journal of neurology
Parkinson's disease onset
upin humans1
1 study
Parkinson's disease onset
upin humans1
Substantia nigra hyperechogenicity predicts Parkinson's disease onset in humans (Patients with essential tremor plus).
“The most significant predictors of conversion were hyperechogenicity of the substantia nigra on transcranial Doppler (TCD), absence of nigrosome-1 on MRI,”
HumansPatients with essential tremor plussubstantia nigra
Multimodal biomarkers of Parkinson’s disease risk in essential tremor. (A prospective cohort study)
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
DLB-specific EEG patterns
upin humans1
1 study
DLB-specific EEG patterns
upin humans1
Substantia nigra hyperechogenicity is associated with DLB-specific EEG patterns in humans (at risk of DLB).
“and a higher prevalence of DLB-specific EEG patterns (driven by females)”
Humansat risk of DLBn = 121
Journal of neural transmission (Vienna, Austria : 1996)
NfL
upin humans1
1 study
NfL
upin humans1
Substantia nigra hyperechogenicity is associated with NfL in humans (at risk of DLB).
“SN+ participants showed higher plasma NfL levels (particularly in males)”
Humansat risk of DLBn = 121
Journal of neural transmission (Vienna, Austria : 1996)
Intracortical facilitation
upin humans1
1 study
Intracortical facilitation
upin humans1
Substantia nigra hyperechogenicity is associated with intracortical facilitation in humans (healthy adults) (p = .005).
“There was a significant positive relationship, however, between area of echogenicity in the right SN and the magnitude of intracortical facilitation in the right (ipsilateral) primary motor cortex (p = .005; multivariate regression)”
Humanshealthy adultsright primary motor cortexn = 23
Journal of neuroscience research