There are 5 papers on Parkinson's disease onset in aging research: 4 observational studies in people, 1 review.
5 papers study it3 more mention it7 findings
1 new paper in 30 daysSee all 8 papers on Parkinson's disease onset
“A polygenic hazard score predicts the onset of PD with a hazard ratio of 3.78 (95% confidence interval 3.49-4.10)”
- Humans4
Interventions
2Nitrogen dioxide
no changein humans1
1 study
Nitrogen dioxide
no changein humans1
Nitrogen dioxide was not clearly linked with Parkinson's disease onset in humans (Overall cohort, over-50s, and sex-stratified samples).
“we found no association between medium-term PM2.5 or NO2 exposure and PD onset in the overall cohort, over-50s, or sex-stratified samples.”
HumansOverall cohort, over-50s, and sex-stratified samplesmedium-term
Exposure to ambient air pollution and onset of Parkinson's disease in a large cohort study
NPJ Parkinson's disease
Fine particulate matter
no changein humans1
1 study
Fine particulate matter
no changein humans1
Fine particulate matter was not clearly linked with Parkinson's disease onset in humans (Overall cohort, over-50s, and sex-stratified samples).
“we found no association between medium-term PM2.5 or NO2 exposure and PD onset in the overall cohort, over-50s, or sex-stratified samples.”
HumansOverall cohort, over-50s, and sex-stratified samplesmedium-term
Exposure to ambient air pollution and onset of Parkinson's disease in a large cohort study
NPJ Parkinson's disease
Associations
5Absence of nigrosome-1
upin humans1
1 study
Absence of nigrosome-1
upin humans1
Absence of nigrosome-1 predicts Parkinson's disease onset in humans (Patients with essential tremor plus).
“The most significant predictors of conversion were hyperechogenicity of the substantia nigra on transcranial Doppler (TCD), absence of nigrosome-1 on MRI,”
HumansPatients with essential tremor plus
Multimodal biomarkers of Parkinson’s disease risk in essential tremor. (A prospective cohort study)
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Substantia nigra hyperechogenicity
upin humans1
1 study
Substantia nigra hyperechogenicity
upin humans1
Substantia nigra hyperechogenicity predicts Parkinson's disease onset in humans (Patients with essential tremor plus).
“The most significant predictors of conversion were hyperechogenicity of the substantia nigra on transcranial Doppler (TCD), absence of nigrosome-1 on MRI,”
HumansPatients with essential tremor plussubstantia nigra
Multimodal biomarkers of Parkinson’s disease risk in essential tremor. (A prospective cohort study)
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Hormone replacement therapy
mixedin humans1
1 study
Hormone replacement therapy
mixedin humans1
Hormone replacement therapy is associated with Parkinson's disease onset in humans (reviewed across heterogeneous clinical studies).
“the findings in support of a role for age at menopause, type of menopause and hormone replacement therapy on Parkinson's disease onset and its core features show inconsistencies”
Reviewreviewed across heterogeneous clinical studiesfemales
Frontiers in aging neuroscience
Epigenetic mutation load
upin humans1OR 1.9
1 study
Epigenetic mutation load
upin humans1OR 1.9
Epigenetic mutation load is associated with Parkinson's disease onset in humans (Epigenetic mutation load across all genes) (OR 1.90, 95% CI 1.52–2.37).
“We found an association for PD onset and EML in all genes (OR = 1.90; 95%CI 1.52-2.37)”
HumansEpigenetic mutation load across all genesblood
Stochastic Epigenetic Mutations Influence Parkinson's Disease Risk, Progression, and Mortality
Journal of Parkinson's disease
Polygenic hazard score
upin humans1HR 3.78
1 study
Polygenic hazard score
upin humans1HR 3.78
Polygenic hazard score predicts Parkinson's disease onset in humans (Highest versus lowest polygenic hazard score risk decile) (HR 3.78, 95% CI 3.49–4.10; highest versus lowest risk decile).
“A polygenic hazard score predicts the onset of PD with a hazard ratio of 3.78 (95% confidence interval 3.49-4.10)”
HumansHighest versus lowest polygenic hazard score risk decile
Genetic Stratification of Age-Dependent Parkinson's Disease Risk by Polygenic Hazard Score
Movement disorders : official journal of the Movement Disorder Society