Subcortical local brain age

17q21.31 haplotype is associated with subcortical local brain age in humans.

“A prominent signal emerged at the 17q21.31 haplotype, encompassing MAPT-related regulatory architecture, with significant associations across all subcortical regions.”

Humanscognitively normal participantsall subcortical regionsn = 41,957

Genome-wide analysis of subcortical aging identifies a spatially structured pattern of genetic associations

GeroScience·1 Aug 2026

common genetic variants are associated with subcortical local brain age in humans (14 significant SNPs across nine independent loci).

“We computed LBA across 14 subcortical structures and identified 14 significant single-nucleotide polymorphisms (SNPs) across nine independent loci.”

Humanscognitively normal participants14 subcortical structuresn = 41,957

Genome-wide analysis of subcortical aging identifies a spatially structured pattern of genetic associations

GeroScience·1 Aug 2026