Regional differences in local brain age

common genetic variants are associated with regional differences in local brain age in humans.

“effect sizes are relatively larger in metabolically central structures such as the pallidum and thalamus compared to limbic regions.”

Humanscognitively normal participantspallidum, thalamus, and limbic regionsn = 41,957

Genome-wide analysis of subcortical aging identifies a spatially structured pattern of genetic associations

GeroScience·1 Aug 2026