SPP1/TREM2 macrophages

Biomarker1 paper1 finding

Interventions

Xenotransplantation

upin humans1+98%Very low certainty

1 study

Xenotransplantation increases SPP1/TREM2 macrophages in humans (98.2%).
“Recipient-derived liver innate immune cells are C1Q-dominant at day 3 and 98.2% SPP1/TREM2 macrophages at day 11”
Human trialpaired pig liver and kidney xenotransplantationliver11 daysn = 1
Multi-omic profiling of paired pig liver and kidney xenografts in a human decedent · Research Square · 25 Aug 2026 · Preprint

Research SquareResearchPreprint26 Aug