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Solute free water clearance

Biomarker

1 paper1 finding

  • Human trial1

Interventions

1

Dapagliflozin

downin humans1

1 study

  1. Dapagliflozin decreases solute free water clearance in humans (-11.0 mL/kg/d (95% CI: -15.94 to -6.07)).

    “leading to proportional reductions in free water clearance (early: -9.1 mL/kg/d [95% CI: -14 to -4.12; P < 0.001]; late: -11.0 mL/kg/d [95% CI: -15.94 to -6.07; P < 0.0001])”

    Human trialheart failure with reduced ejection fraction10 mg daily4 weeksn = 29

    Water Conservation Overrides Osmotic Diuresis During SGLT2 Inhibition in Patients With Heart Failure

    Journal of the American College of CardiologyApr 11, 2024

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