There are 4 papers on soluble TNFR1 in aging research: 4 observational studies in people.
4 papers study it1 more mentions it4 findings
See all 5 papers on soluble TNFR1
“Five biomarkers, sCD14, hsCRP, WBC, sTNFR1, and sIL2Rα, were associated with incident PAD.”
- Humans4
Effects
2Physical function
downin humans1
1 study
Physical function
downin humans1
Soluble TNFR1 is linked with lower physical function in early-agers with frailty and co-morbidities (-0.4 ± 0.2 points per 500 pg/mL TNFR1, p = 0.0207).
“Each 500 pg/mL of TNFR1 was associated with -0.4 ± 0.2 point in SPPB (p = 0.0207)”
Humansin early-agers with frailty and co-morbiditiesn = 100
The journal of nutrition, health & aging
Grip strength
downin humans1
1 study
Grip strength
downin humans1
Soluble TNFR1 is linked with lower grip strength in early-agers with frailty and co-morbidities (-1.9 ± 0.6 kg per 500 pg/mL TNFR1, p = 0.0008).
“each 500 pg/mL of TNFR1 was associated with -1.9 ± 0.6 (p = 0.0008)”
Humansin early-agers with frailty and co-morbiditiesn = 100
The journal of nutrition, health & aging
Associations
2Incident clinical peripheral artery disease
upin humans1
1 study
Incident clinical peripheral artery disease
upin humans1
Soluble TNFR1 is associated with incident clinical peripheral artery disease in humans (adjusted for demographic, behavioral, and clinical risk factors).
“Five biomarkers, sCD14, hsCRP, WBC, sTNFR1, and sIL2Rα, were associated with incident PAD.”
Humansadjusted for demographic, behavioral, and clinical risk factorsmedian follow-up 13.9 yearsn = 5,061
AHA Scientific Sessions 2025 abstract
Memory Z-score
downin humans1
1 study
Memory Z-score
downin humans1
Soluble TNFR1 is associated with memory Z-score in humans (men and women combined; per one SD increase in baseline sTNFR1) (adjusted difference in slopes = -0.09, p = 0.02).
“a one SD increase in baseline sTNFR1 was associated with a faster rate of decline in memory Z-score (adjusted difference in slopes = -0.09, p = 0.02)”
Humansmen and women combined; per one SD increase in baseline sTNFR17 yearsn = 1,010
Sex-specific associations of inflammation markers with cognitive decline
Experimental gerontology