SIRT6 C-terminal phosphorylation sites

SIRT6 C-terminal phosphorylation sites are associated with lifespan in mammals.

“We find that the presence and use of these sites is strongly correlated with maximum lifespan across mammals.”

AnimalsAcross mammals

Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress

bioRxiv : the preprint server for biology·24 Apr 2026Preprint