Serum uric acid reduction

1. SGLT2 inhibitors increase serum uric acid reduction in humans (B = 22.62, p = 0.040).

   “At 12 months, SGLT2 inhibitor treatment was associated with greater ΔsUA compared with allopurinol (B = 22.62, p = 0.040)”

   Humanstype 2 diabetes mellitus and hyperuricemia, vs allopurinol12 months

   Exploratory Mediation-Informed Analysis and Dose-Response Analysis of Uric Acid Reduction and Kidney Outcomes in SGLT2 Inhibitor Therapy Compared to Allopurinol

   Medical sciences (Basel, Switzerland)·23 Jul 2026

More on SGLT2 inhibitors

1. Serum uric acid reduction has no effect on renoprotective effects in humans.

   “Reductions in sUA do not appear to mediate the renoprotective effects of SGLT2 inhibitors.”

   Humansin SGLT2 inhibitor-treated patients with type 2 diabetes and hyperuricemia

   Exploratory Mediation-Informed Analysis and Dose-Response Analysis of Uric Acid Reduction and Kidney Outcomes in SGLT2 Inhibitor Therapy Compared to Allopurinol

   Medical sciences (Basel, Switzerland)·23 Jul 2026