Estimated glomerular filtration rate change

1. SGLT2 inhibitors are associated with estimated glomerular filtration rate change in humans (B = -6.14, p < 0.001).

   “its direct association with ΔeGFR remained significant after adjustment for ΔsUA (B = -6.14, p < 0.001).”

   Humanstype 2 diabetes mellitus and hyperuricemia, vs allopurinol, adjusted for ΔsUA12 months

   Exploratory Mediation-Informed Analysis and Dose-Response Analysis of Uric Acid Reduction and Kidney Outcomes in SGLT2 Inhibitor Therapy Compared to Allopurinol

   Medical sciences (Basel, Switzerland)·23 Jul 2026

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