Serine

Biomarker2 papers1 finding

Humans1
Animals1

Interventions

1

L-serine

upin mice1Very low certainty

1 study

L-serine increases serine in mice.
Animalsin 3xTg-AD mice
L-serine-enriched diet restores impaired adult neurogenesis in the hippocampus of 3xTg-AD mice · Journal of Alzheimer's disease : JAD · 16 Sep 2026

Funding

National Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$430.8k1 grant since 2026

An Oleoyl Serine Derivative as an Innovative Therapeutic Approach for Osteoporosis
National Institute of Arthritis and Musculoskeletal and Skin DiseasesBeth Israel Deaconess Medical CenterUS$430.8k2026–2028

Latest

10

bioRxivHumansPreprint22 Sep

Metabolomics highlights cardiovascular risk factor links to sphingolipid and one-carbon metabolism in asymptomatic adults

Amino acid metabolism

Journal of Alzheimer's DiseaseAnimals16 Sep

L-serine-enriched diet restores impaired adult neurogenesis in the hippocampus of 3xTg-AD mice

Aging and DiseaseAnimals3 Sep

Myo-Inositol Dampens Apathetic Symptoms in Aged Mice and Is Associated with Sex-Specific Synapse Remodelling

Bone ResearchAnimals3 Sep

Inhibition of ERK5 activity ameliorates osteoarthritis by suppressing NLRP3 inflammasome-mediated chondrocyte pyroptosis

NLRP3 inflammasome

GSA 2025 AbstractModel organisms3 Jan

Modulation of Serine Metabolism Improves Health and Longevity in Drosophila Melanogaster

GSA 2025 AbstractAnimals3 Jan

Ceramide-Lowering Therapy Improves Metabolic Health in Aged UM-HET3 Mice Fed a Western Diet

AAIC 2025 AbstractHumans25 Dec

Insulin Resistance in Human Hippocampal Pyramidal Neurons Correlates with Age in Cognitively Normal and Alzheimer's Disease Patients

AAIC 2025 AbstractHumans24 Dec

Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration

AAIC 2025 AbstractAnimals24 Dec

Tau pathology in triple knock‐in mouse model of Alzheimer's Disease expressing APOE3 and APOE4

AHA Scientific Sessions 2025 AbstractHumans3 Nov

Longitudinal protein associations with impaired fasting glucose (IFG) and diabetes in MESA