What does the research say about Senescent cancer-associated fibroblast density?

Senescent cancer-associated fibroblast density

There is 1 paper on senescent cancer-associated fibroblast density in aging research: none in people yet, 1 in animals. The newest story, Oct 28, 2026: “Drug pair eliminated breast cancer tumors in animals’ bones”.

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“In patient bone metastases, senCAF density and active MK2 signaling predict reduced overall survival.”

Targeting MK2-Driven Stromal Senescence Sensitizes Breast Cancer Bone Metastasis to ImmunotherapybioRxiv2026doi:10.64898/2026.10.26.761990

Animals1

Associations

Overall survival

downin humans1

1 study

Senescent cancer-associated fibroblast density predicts overall survival in humans (breast cancer bone metastasis).
“In patient bone metastases, senCAF density and active MK2 signaling predict reduced overall survival.”
Humansbreast cancer bone metastasisbone metastasis
Drug pair eliminated breast cancer tumors in animals’ bones
bioRxivOct 28, 2026Preprint

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1 paper in 12 months

bioRxivOct 28

Drug pair eliminated breast cancer tumors in animals’ bones

In animal experiments, blocking a signaling protein and stimulating immune cells also produced lasting immune memory when the animals faced cancer again.In animal experiments, blocking a signaling protein and stimulating immune cells also produced lasting immune memory when the animals faced cancer again.

Preprint: animal studyBreast cancer

Paper

Senescent cancer-associated fibroblast density

Associations

Latest

Drug pair eliminated breast cancer tumors in animals’ bones

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