SEMA3C

There are 2 papers on SEMA3C in aging research: 1 trial in people. The newest story, Nov 9, 2026: “A heart support cell group sustains nerves and pumping in mice”.

Biomarker

2 papers study it2 more mention it3 findings

1 new paper in 30 daysSee all 4 papers on SEMA3C

  • Human trial1
  • In silico1

Interventions

1

Astaxanthin supplementation combined with CrossFit training

downin humans1

1 study
  1. Astaxanthin supplementation combined with CrossFit training decreases SEMA3C in humans (greater reduction compared with astaxanthin alone (SG) in males with obesity).

    “Significant differences were found in the reductions of plasma levels of vaspin, visfatin, apelin, RBP4, chemerin, and SEMA3C between the SG and TSG groups (p < 0.05).”

    Human trialgreater reduction compared with astaxanthin alone (SG) in males with obesitycapsule20 mg/day12 weeksmales

    Astaxanthin Supplementation Augments the Benefits of CrossFit Workouts on Semaphorin 3C and Other Adipokines in Males with Obesity

    Nutrients

More on Astaxanthin supplementation combined with CrossFit training

Associations

2

Low hand grip strength

upin silico1OR 1.059

1 study
  1. SEMA3C raises the risk of low hand grip strength in silico (Mendelian randomization analysis) (OR = 1.059, 95 % CI 1.010-1.110, P = 0.018).

    “higher plasma levels of SEMA3C are associated with an increased risk of CAD (OR = 1.068, 95 % CI 1.012-1.128, P = 0.016) and low hand grip strength (HGS) (OR = 1.059, 95 % CI 1.010-1.110, P = 0.018)”

    In silicoMendelian randomization analysis

    Identifying semaphorin 3C as a biomarker for sarcopenia and coronary artery disease via bioinformatics and machine learning

    Archives of gerontology and geriatrics

Coronary artery disease

upin silico1OR 1.068

1 study
  1. SEMA3C raises the risk of coronary artery disease in silico (Mendelian randomization analysis) (OR = 1.068, 95 % CI 1.012-1.128, P = 0.016).

    “higher plasma levels of SEMA3C are associated with an increased risk of CAD (OR = 1.068, 95 % CI 1.012-1.128, P = 0.016)”

    In silicoMendelian randomization analysis

    Identifying semaphorin 3C as a biomarker for sarcopenia and coronary artery disease via bioinformatics and machine learning

    Archives of gerontology and geriatrics

More on Coronary artery disease

Latest

Dec 2025: 1Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 12 papers in 12 months
AHA Scientific Sessions 2026 Abstract

A heart support cell group sustains nerves and pumping in mice

Loss of the cell group reduced the share of blood pumped out of the left ventricle per beat from 84.0% to 68.8%.Loss of the cell group reduced the share of blood pumped out of the left ventricle per beat from 84.0% to 68.8%.

Mouse studyMechanisms