RISC-bound sRNA 6mer seed toxicity

1. Amyloid-beta 42 increases RISC-bound sRNA 6mer seed toxicity in cells.

   “RISC-bound sRNAs show a shift to more toxic 6mer seeds compared to controls.”

   Cellscells exposed to Aβ42 oligomersoligomers

   Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer’s disease and aging

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 10, 2022Preprint

More on Amyloid-beta 42

1. Superager status is associated with RISC-bound sRNA 6mer seed toxicity in humans.

   “RISC-bound sRNAs are shifted to more nontoxic 6mer seeds.”

   HumansSuperAgers with superior memory performancebrain

   Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer’s disease and aging

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 10, 2022Preprint

1. Alzheimer's disease is associated with RISC-bound sRNA 6mer seed toxicity in human cells.

   “RISC-bound sRNAs show a shift to more toxic 6mer seeds compared to controls.”

   Cellsneurons derived from Alzheimer's disease patientsinduced pluripotent stem cell-derived neuron

   Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer’s disease and aging

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 10, 2022Preprint

More on Alzheimer's disease

1. Alzheimer's disease and aging is associated with RISC-bound sRNA 6mer seed toxicity in mice.

   “RISC-bound sRNAs show a shift to more toxic 6mer seeds compared to controls.”

   Animalsmouse Alzheimer's disease models and aging brainbrain

   Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer’s disease and aging

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 10, 2022Preprint