2 papers1 finding
All-cause dementia
upin humans1HR 1.71
Rest-activity rhythm amplitude raises the risk of all-cause dementia in humans (HR 1.71, 95% CI 1.26-2.33).
“participants in the lowest quartile of amplitude or mesor exhibited increased ACD risk relative to individuals in the middle two quartiles, but only in the 66‐70 group (hazard ratio, HR [95% confidence interval, CI] for amplitude: 1.71 [1.26,2.33]”
Humanslowest quartile compared to middle two quartiles
Age‐dependence of the link between circadian rest‐activity rhythm parameters and incident dementia
AAIC 2025 abstract23 Dec 2025
A 0.1-unit higher score for broken-up rest and activity was linked to 1.15 times the death rate among 3,061 adults.A 0.1-unit higher score for broken-up rest and activity was linked to 1.15 times the death rate among 3,061 adults.