Regulatory T cell frequency

1. Nicotinamide increases regulatory T cell frequency in an ITP murine model.

   “Supplementation with NAD+ precursor nicotinamide (NAM), but not nicotinamide mononucleotide (NMN), increased Treg frequency and ameliorated thrombocytopenia in an ITP murine model”

   Animalsin an ITP murine model

   Nicotinamide enhances Treg differentiation by promoting Foxp3 acetylation in immune thrombocytopenia

   British journal of haematology·Oct 15, 2024

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1. Lactobacillaceae is associated with regulatory T cell frequency in humans (Senescent-INRs, ex vivo).

   “Lactobacillaceae family and metabolites (members of the butyrate family – i.e. α-ketobutyrate) were correlated with Treg frequencies in “Senescent-INRs” ex vivo”

   HumansSenescent-INRs, ex vivo

   Microbiome and Metabolome driven differentiation of TGF-β producing Tregs leads to Senescence and HIV latency

   bioRxiv (Cold Spring Harbor Laboratory)·Dec 15, 2020Preprint

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1. Fluad is associated with regulatory T cell frequency in humoral responders versus non-responders.

   “one of the few differences seen between the two groups was higher frequencies of regulatory T-cells in R”

   Human trialin humoral responders versus non-respondersperipheral blood

   Frequencies of peripheral immune cells in older adults following seasonal influenza vaccination with an adjuvanted vaccine

   Vaccine·Jul 6, 2017

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