What does the research say about regional amyloid-beta burden?

Regional amyloid-beta burden

There are 2 papers on regional amyloid-beta burden in aging research: 1 observational study in people, 1 in animals. The newest story, Nov 4, 2026: “Brain protein’s links to thinking varied across regions”.

Biomarker

2 papers study it4 findings

1 new paper in 30 daysSee all 2 papers on regional amyloid-beta burden

“Precuneus Aβ showed a topology-independent association with cognition, defining an amyloid-dominant pathway.”

Network-Dependent and Amyloid-Dominant Pathways Link Early Regional Amyloid to Cognition Before Global Amyloid PositivityResearch Square2026doi:10.21203/rs.3.rs-11565606/v1

Humans1
Animals1

Associations

Cognitive function

downin humans1mixedin humans1

1 study

Regional amyloid-beta burden predicts cognitive function in humans (HABS).
“regional Aβ in several topology-dependent regions predicted cognitive decline over 3- and 8-year follow-up in HABS”
HumansHABStopology-dependent brain regions3- and 8-year follow-up
Brain protein’s links to thinking varied across regions
Research SquareNov 3, 2026Preprint
Regional amyloid-beta burden is associated with cognitive function in humans (globally amyloid-β-negative individuals; independent of network topology).
“Precuneus Aβ showed a topology-independent association with cognition, defining an amyloid-dominant pathway.”
Humansglobally amyloid-β-negative individuals; independent of network topologyprecuneus
Brain protein’s links to thinking varied across regions
Research SquareNov 3, 2026Preprint

Global amyloid progression

upin humans1

1 study

Regional amyloid-beta burden predicts global amyloid progression in humans.
“precuneus Aβ consistently predicted subsequent global amyloid progression.”
Humansprecuneus
Brain protein’s links to thinking varied across regions
Research SquareNov 3, 2026Preprint

Latest

2 papers in 12 months

Research SquareNov 4

Brain protein’s links to thinking varied across regions

In people below the cutoff for widespread amyloid buildup, an observational study found that some links to thinking abilities varied with brain connections.In people below the cutoff for widespread amyloid buildup, an observational study found that some links to thinking abilities varied with brain connections.

Preprint: cohort studyMechanisms

Paper

Research SquareMar 16

Alzheimer's Disease Neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

Preprint: experiments in 24 dogsMechanisms