Research Square
Brain protein’s links to thinking varied across regions
In people below the cutoff for widespread amyloid buildup, an observational study found that some links to thinking abilities varied with brain connections.In people below the cutoff for widespread amyloid buildup, an observational study found that some links to thinking abilities varied with brain connections.
Preprint: cohort studyMechanisms
Who was studiedGlobally amyloid-negative individuals, 6 to 110 months
What changedAmyloid’s links to thinking varied across brain regions, depending on network connections in some regions but not the precuneus
The catchThinking was measured using a cognitive composite score, a proxy for everyday cognitive functioning