RBFOX1 somatic mutations

Age is associated with RBFOX1 somatic mutations in humans.

“we found two sites to have significantly more mutations in older individuals (16:6899517 ( RBFOX1 ), p = 0.044; 4:21788463 ( KCNIP4 ), p = 0.045).”

Humanssite 16:6899517excitatory neuron

Identifying aging and Alzheimer’s disease associated somatic mutations in excitatory neurons from the human frontal cortex using whole genome sequencing and single cell RNA sequencing data

medRxiv·May 26, 2022Preprint