KCNIP4 somatic mutations

Age is associated with KCNIP4 somatic mutations in humans.

“we found two sites to have significantly more mutations in older individuals (16:6899517 ( RBFOX1 ), p = 0.044; 4:21788463 ( KCNIP4 ), p = 0.045).”

Humanssite 4:21788463excitatory neuron

Identifying aging and Alzheimer’s disease associated somatic mutations in excitatory neurons from the human frontal cortex using whole genome sequencing and single cell RNA sequencing data

medRxiv·May 26, 2022Preprint